(Yes, there's not a hyphen in Metro Style apps. I don't get it, but I'm sure some day it will be made clear.)
Since attending the Build conference that Microsoft held in September, I've been the proud owner of a Samsung tablet device running the Developer Preview build of Windows 8, along with a preview version of Visual Studio 11 Express. Given these tools, the only kinds of apps I can build are native Windows 8 Metro style apps--you know, the ones that run full screen, are "fast and fluid", and look really BIG.
Like the new UI or not, one thing is sure: the whole concept of Metro style apps is based on the HTML5/CSS3/JavaScript stack. Sure, you can create apps using C#/VB/C++ and XAML, and that works fine if you're already comfortable with those technologies. But if you're starting on developing WIndows apps now, and want to create Metro style apps, I would certainly contemplate jumping right into the JavaScript world.
Coming from a VB/C#/XAML background, I didn't find the transition to JavaScript particularly easy--I'm still struggling a little. Since IntelliSense support in Visual Studio 11 for JavaScript is there, but not particularly specific, using IntelliSense to help guide you as you create code will generally be not much help. It may improve over time, but since JavaScript relies on being late bound, it's awfully hard for the tool to predict the data type of the assignment without some contextual information.
On the other hand, using HTML and CSS to create layout means that you're taking advantage of tools and technologies that also allow you to use your skills creating Web sites, and there's something to be said for that.
It remains to be seen how well the Microsoft Store will do with consumers, but I'd bet that this is a really good time to start creating useful, touch-aware Metro applications for sale in the Microsoft Store. Once the "doors open", we'll see a lot of applications become available. I'm waiting to see how business applications, such as word processors and spreadsheets, do in a finger-driven world. Using Excel on the Windows desktop, on the Samsung tablet, is a bit of a challenge without a keyboard and mouse. No consumer will put up with this, and business productivity will require finger-sensitive replacement applications. It works on the iPad, it can work in Windows 8 as well.
It's worth downloading the Developer Preview (or the upcoming beta) of Windows 8 to spend some time with it. It's going to be an interesting 2012, that's for sure!